| 黄芪甲苷、总多糖、注射液对3种人恶性肿瘤细胞增殖的影响 |
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| 引用本文： | 秦旭华,金沈锐,瞿燕. 黄芪甲苷、总多糖、注射液对3种人恶性肿瘤细胞增殖的影响[J]. 中药药理与临床, 2006, 22(6): 26-27 |
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| 作者姓名： | 秦旭华 金沈锐 瞿燕 |
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| 作者单位： | 1. 成都中医药大学,药学院,中药教研室,成都,610075
2. 成都中医药大学,基础医学院,生物化学与分子生物学教研室,成都,610075 |
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| 基金项目： | 成都中医药大学校科研和教改项目 |
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| 摘 要： | 目的:比较黄芪不同制剂、成分对3种人肿瘤细胞株SMMC7721、PC3、HL60增殖的影响。方法:将不同浓度黄芪甲苷、总多糖、注射液,直接加入肿瘤细胞培养液中,MTT法测定各成分对三种肿瘤细胞的增殖影响。结果:黄芪甲苷、总多糖、注射液上述三种人肿瘤细胞增殖无明显抑制作用,且黄芪甲苷在20mg/ml浓度时对SMMC7721、PC3的增殖有一定促进作用。结论:体外实验结果表明黄芪甲苷、总多糖、注射液对三种人肿瘤细胞株增殖无明显抑制作用。
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| 关 键 词： | 黄芪甲苷 黄芪总多糖 黄芪注射液 抑瘤作用 |
Antitumous effects of Astragalus polysaccharide, Astragaloside IV and Astragalus mongholicus injection on diverse human malignant tumor cell strains(SMMC7721,PC-3,HL-60) |
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| Qin Xuhua,Jin Shenrui,Qu Yan. Antitumous effects of Astragalus polysaccharide, Astragaloside IV and Astragalus mongholicus injection on diverse human malignant tumor cell strains(SMMC7721,PC-3,HL-60)[J]. Pharmacology and Clinics of Chinese Materia Medica, 2006, 22(6): 26-27 |
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| Authors: | Qin Xuhua Jin Shenrui Qu Yan |
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| Affiliation: | 1. College of Pharmacy, Chengdu University of TCM, Chengdu 610075 ; 2.College of Preclinical Medicine, Chengdu University of TCM, Chengdu 610075 |
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| Abstract: | Objective: To study the effect of Astragalus polysaccharide,Astragaloside IV and Astragalus mongholicus injection on diverse human malignant tumor cell strains. Method: Using different concentrations of Astragalus polysaccharide,Astragaloside IV and Astragalus mongholicus injection to treat diverse human malignant tumor cell strains(SMMC7721, PC-3, HL-60)in vitro. After 48 hours, status of multiplication of tumor cell strains being detected by the method of MTT. Result: Astragalus polysaccharide,Astragaloside IV and Astragalus mongholicus injection show no depressant effects of cell multiplication of human malignant tumor cell strains (P>0.05),meanwhile Astragaloside IV(20mg/ml)show promote cell multiplication. Conclusion: Astragalus polysaccharide,Astragaloside IV and Astragalus mongholicus injection have not antitumous effect in vitro,the reasons maybe come from the different mechanism of action between in vitro and in vivo . |
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| Keywords: | astragalus polysaccharide astragaloside IV Astragalus mongholicus injection antitumous effect |
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