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Strategies for B-lymphocyte repertoire remodeling in transplantation tolerance |
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| Authors: | Vivek Kumar Mustafa Moiz M Rodriguez Eduardo Redfield Robert R Parsons Ronald F Rostami Susan Migone Thi-Sau Cancro Michael P Naji Ali Noorchashm Hooman |
| Affiliation: | (1) Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA;(2) Human Genome Sciences, Inc., Rockville, MD, USA;(3) Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA |
| Abstract: | Transplantation tolerance remains an elusive goal as B-cell-initiated chronic humoral rejection evades current immunosuppression. B-cell-directed therapy is thus emerging as a key component in achieving transplantation tolerance and long-term graft survival. Here, we propose strategies of B-cell repertoire remodeling to achieve humoral unresponsiveness to donor antigens with implementation of fundamental B-cell immunobiology and use of newly developed B-cell-directed agents. |
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