屈光参差性弱视mfVEP的临床分析

目的分析屈光参差性弱视患者多焦视觉诱发电位(mfVEP)的特征性变化,以探讨弱视发病的可能机制。方法采用VERISScienceTM4.2多焦电生理系统对23例屈光参差性弱视患者、30例正常人进行双眼图形mfVEP检查,以潜伏期与振幅为分析指标,进行了屈光参差性弱视眼、对侧眼和正常对照三组mfVEP的对比研究。结果在六个离心度上弱视眼反应振幅密度较其对侧眼和正常眼均显著降低,潜伏期延长。弱视眼波形异常程度随离心度增加而减小,在六个离心度上弱视眼mfVEP的波形异常程度都与弱视眼的视力异常程度有相关性。结论屈光参差性弱视患者的mfVEP具有明显的特征性改变,表明弱视患者的视觉传导通路存在明显损害,在中心区损害重于周边区,弱视眼波形异常程度与视力异常程度有明显的相关性,mfVEP检查对于弱视的诊断、治疗和预后判断具有一定的指导意义。

Investigation of characteristic changes in anisometropic amblyopia by multifocal VEP

Objective To investigate the characteristic changes in anisometropic amblyopia by multifocal VEP ,to study the possible mechanism of amblyopia. Methods The multifocal pattern VEP of both eyes of 23 anisometropic amblyopes and 30 normal subjects were recorded. Results In amblyopic eyes at six eccentricities the mfVEP response amplitudes were reduced and the latencies were prolonged compard with the fellow eyes and the normal eyes. The abnormalities of the characteristic waveform of the amblyopic eyes decreased with the eccentricity increased, and the abnormalities were correlated with the damage of visual acuity of the amblyopic eyes at six eccentricities. Conclusion Multifocal VEP of anisometropic amblyopia showed characteristic changes mean the existence of impairment in visual pathway. The degree of abnormality was lessened with the eccentricity increased and was correlated with the damage of visual acuity. The results suggest that multifocal VEP could be used in instructing the diagnosis and treatment of amblyopia.