糖尿病患者颈动脉粥样硬化与脂蛋白（a）关系探讨

目的 观察糖尿病患者颈动脉粥样硬化的程度,探讨2型糖尿病患者血脂与颈动脉硬化的关系。方法 对51例2型糖尿病患者和21例健康对照组采用彩色多普勒显像仪检查双侧颈总动脉平均内膜-中层厚度（IMT）,糖尿病组根据血管内径狭窄程度依次分为内膜正常组、内膜增厚组、斑块形成组。采用免疫透射比浊法测定血清脂蛋白（a）LP（a）],同时测定患者血清甘油三酯（TG）,总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及空腹血糖（FPG）。比较各糖尿病组与对照组的IMT及各项血脂、血糖水平,并进行相关分析。结果 随着IMT程度加重,血浆LP（a）水平逐渐升高,与健康对照组相比,内膜增厚组及斑块形成组LP（a）差异有显著性（P〈0.001）。结论 LP（a）水平增高是动脉粥样硬化性疾病的独立危险因素。

Study on the relationship between the level of carotid atherosclerosis and serum lipid in type 2 diabetes

Objective To study the relationship between the severity of carotid atherosclerosis and serum lipid level in type 2 diabetes. Methods The intimal - medial thickness （IMT） of commod carotid arteries were measured by B - mode ultrasound. The serum total cholesterol（TC） ,triglycerids（TG）, low density lipoprotein（LDL） and lipoprotein（a）（LPa） were determined simultaneously. 51 eases of type 2 diabetes mellitus patients were divided into the normal group, intimal thieking group and the plaque shaping group aeeording to the severity of vascular stenosis. 21 normal persons were regarded as control group. Results When stenosis of IMTbeeame severer, serum level of LP（ a） got higher. The levels of LP（ a） wessignifieantly higher than control greup（P 〈 0.05）. Conclusions Elevated serum level of LP（a） is an independent risk factor of atheroaclerosis diseases.