| 血红素氧合酶在去势大鼠阴茎海绵体的表达 |
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| 引用本文： | 刘竞,姜睿.血红素氧合酶在去势大鼠阴茎海绵体的表达[J].中华男科学杂志,2009,15(3):212-217. |
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| 作者姓名： | 刘竞 姜睿 |
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| 作者单位： | 泸州医学院附属医院泌尿外科,四川,泸州,646000 |
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| 基金项目： | 四川省教育厅课题，四川省卫生厅课题，四川省科技厅课题 |
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| 摘 要： | 目的:研究血红素氧合酶(HO)在去势大鼠阴茎海绵体的表达,探讨其在雄激素缺乏的勃起功能障碍发生中的机制。方法:40只10周龄雄性SD大鼠随机分成:假手术2周组(A组),假手术4周组(B组),去势2周组(C组),去势4周组(D组)。术后2、4周检测血清睾酮水平,免疫组化及RT-PCR技术检测HO及nNOS在大鼠阴茎海绵体的表达。结果:去势组大鼠较假手术组血清睾酮水平显著下降,AvsC:(283.222±117.171)ng/dlvs(7.117±3.700)ng/dl;BvsD:(289.280±87.413)ng/dlvs(48.826±19.477)ng/dl](P<0.01)、HO-1、HO-2蛋白表达明显降低(P<0.01),去势组HO-1、HO-2及nNOSmRNA表达较假手术组显著降低(P<0.01)。结论:雄激素可能通过HO-CO系统部分调控阴茎勃起功能。
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| 关 键 词： | 血红素氧合酶 神经型一氧化氮合酶 雄激素 阴茎海绵体 大鼠 |
Expression of Heme Oygenase in the Corpus Cavernosum of Castrated Rats |
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| LIU Jing,JIANG Ru.Expression of Heme Oygenase in the Corpus Cavernosum of Castrated Rats[J].National Journal of Andrology,2009,15(3):212-217. |
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| Authors: | LIU Jing JIANG Ru |
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| Institution: | LIU Jing,JIANG Rui Department of Urology,The Affiliated Hospital of Luzhou Medical College,Luzhou,Sichuan 646000,China |
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| Abstract: | Objective:To study the expression of heme oxygenase(HO)in the corpus cavernosum of castrated rats and to investigate its role in androgen deficiency-mediated erectile dysfunction.Methods:Forty 10-week old SD rats were randomly divided into Groups A(2-week sham operation),B(4-week sham operation),C(2-week castrated)and D(4-week castrated).The serum testosterone level was determined,and the expressions of HO and nNOS in the corpus cavernosum of the castrated rats were detected by immunohistochemical staining ... |
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| Keywords: | heme oxygenase neuronal nitric oxide synthase androgen corpus cavernosum rat |
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