兰索拉唑与法莫替丁预防呼吸衰竭并发应激性溃疡的疗效对比

目的对比兰索拉唑与法莫替丁预防呼吸衰竭并发应激性溃疡的疗效。方法 86例慢性阻塞性肺病(COPD)、肺源性心脏病并发呼吸衰竭患者,随机分为观察组(以兰索拉唑进行干预,n=45)和对照组(以法莫替丁进行干预,n=41),比较两组的疗效。结果观察组应激性溃疡发生率低于对照组,治疗7 d后胃液pH值改善优于对照组,差异具有统计学意义(P<0.05);两组纠正呼吸衰竭所需时间相仿,差异无有统计学意义(P>0.05)。结论兰索拉唑与法莫替丁相比,更能降低COPD、肺源性心脏病并呼吸衰竭时应激性溃疡的发生率,值得临床推广。

A comparative study on efficacy of lansoprazole and famotidin in prevention of stress ulcer complicated with respiratory failure.

Objective To explore the efficacy of lansoprazole and famotidin in prevention of stress ulcer complicated with respiratory failure. Methods Eighty six patients with chronic obstructive pulmanary disease and chronic eorpulmonale complicated with stress ulcer were studied by randomized double blind method and they were divided into two groups. Patients in observation group （ n = 45 ） were treated with lansoprazole, whereas patients in control group （n = 41 ） were treated with famotidin. The incidence rates of peptic ulcer and pH value of gastric juice were de- tected at 7 days after treatment in both groups. Results The occurrence of stress ulcer in observational group was lower than that of control group, and the improvement of pH in gastric juice, was better than that of control group. There was significantly statistical difference between these two groups （ P 〈 0.05 ）. Conclusion The efficacy of lansoprazole in prophylaxis of stress ulcer complicated with respiratory failure is better than that of famotidin, and it is worthy to be recommended for clinical application.