胃肠间质瘤45例诊治分析

目的探讨胃肠间质瘤(GIST)的诊断和治疗。方法回顾性分析2004年1月至2011年12月收治的经手术治疗的45例GIST病人的临床资料。结果 45例病人均行手术,术后病理确诊为GIST。其中胃部19例,十二指肠2例,小肠17例,结直肠5例,腹腔多发病灶2例。42例完整手术切除,3例因肿瘤较大或广泛转移行局部切除或活检。结论 GIST首选治疗方法是外科手术,术后辅助应用甲磺酸伊马替尼可减少复发和改善预后。

Study on diagnosis and treatment of gastrointestinal stromal tumor in 45 cases

Objective To explore the method for diagnosis and treatment of gastrointestinal stromal tumor （GIST）. Methods The clinical data of 45 cases of GIST treated by surgical operation in this hospital during January 2004 to December 2011 were retrospectively analyzed. Resuits These 45 patients had been operated and GIST had been proved by pathological examination. In this series of patients, the tumor had been found in stomach （n = 19）, duodenum （n =2）, small intestine （n = 17）, colon and rectum （n =5） and abdominal cavity （n =2）. GIST in forty - two cases had completely been resected, and GIST of 3 cases only underwent palliative resection or biopsy because of extensive metastasis. Conclusion The first choice for treatment of GIST is curative resection, and adjuvant therapy with imatinib mesylate can reduce the recurrence of tumor, thus it may improve the prognosis and raise the survival rate of patients.