兔动脉硬化时脑血管血液动力学参数变化及相关性分析

本文报道了兔动脉硬化时，脑血管血液动力学参数（ＣＶＨＰ）的变化。动脉硬化组（ＡＳ组）颈动脉平均血流量（Ｑｍｅａｎ）、平均血流速度（Ｖｍｅａｎ）、最大血流速度（Ｖｍａｘ）、最小血流速度（Ｖｍｉｎ）和脑血管零压顺应性（ＣＯ）显著降低（Ｐ＜０．０５～０．０１），脑血管外周阻力（Ｒ）及脑血管特性阻抗（Ｚｃ）显著升高（Ｐ＜０．０５及０．００１）。颈动脉病变程度与Ｑｍｅａｎ、Ｖｍｅａｎ和ＣＯ有显著负相关（Ｐ＜００５），与Ｒ和Ｚｃ有显著正相关（Ｐ＜００５及０．０１）。Ｑｍｅａｎ与Ｖｍｅａｎ、Ｖｍａｘ和ＣＯ有显著正相关（Ｐ＜０．０５～０．０１），与Ｒ和Ｚｃ有显著负相关（Ｐ＜０．０１及０．０５）．对照组（Ｃ组）与ＡＳ组回归方程比较，Ｑｍｅａｎ－Ｖｍａｘ和Ｑｍｅａｎ－Ｒ斜率ｂ有显著差别（Ｐ＜０．０１及０．００１）；Ｑｍｅａｎ－Ｖｍｅａｎ、Ｑｍｅａｎ－ＣＯ和Ｑｍｅｎａ－Ｚｃ截矩ａ有显著差别（Ｐ＜０．０５～０．０１）。

THE CHANGES OF CEREBROVASCULAR HEMODYNAMIC PARAMETERS AND THE RELATIONAL ANALYSIS UNDER THE CONDITION OF ARTERIOSCLEROSIS IN RABBITS

In the experimental rabbit arteriosclerosis,the changes of the cerebrovascular hemodynamic parameters(CVHP) and the relationship were observed.In arteriosclerosis group(AS group). the mean flow(Q_(mean)), Mean velocity(V_(mean)), Maximal velocity(V_(max)) and minimal velocity(V_(min)) of the carotid blood flow and cerebrovascular compiance for zero pressure(co) were significantly decreased (p<0.05,0.01), but the values of cerebrovascular peripheral resistance(R) and characteristic impedance(Zc) were significantly increased(P<0.05 and 0.01) as compared with those in control group(C group). The values of Q_(mean), V_(mean),and CO showed siguificant negative correlation (P<0.05,0.01) but those of R and Zc showed siguificant positive correlation (P<0.01 and 0.05) with the carotid lesions.When compared the linear equations of AS group with those of C group,the regression coefficient b of Q_(mean)-V_(max) and Q_(mean)-R showed significant difference (P<0.01 and 0.001);the intercept a of Q_(mean)_V_(mean),Q_(mean)-CO and Q_(mean) Zc showed significant diffenence (P<0.05,0.01)