青心酮对妊高征患者及其胎血浆心钠素与环核苷酸水平的影响

将32例妊娠高血压综合征（PIH）患者随机分为PIH组（15例）和青心酮（DHAP）治疗组（17例）,同时取相应年龄未孕妇女(16例）及正常孕妇（15例)作为对照组。采用放射免疫技术测定各组外周血（母血）、脐静脉血（胎血）的心纳素（ANP)、环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）水平。结果发现:正常孕妇血浆ANP及cAMP、cGMP水平较未孕者略有增高,但无统计学意义（P>0.05）;而 PIH患者母血ANP及cGMP较未孕或正常孕妇明显增高（P

The Influence of 3,4-Dihydroxyacetophynone on the Levels of Atrial Natriuretic Polypeptide,cGMP and cAMP in Maternal and Fetal Plasma from PIH-Patients

Thirty-two nulliparous Pregnancy-induced hypertension (PIH) patients were randomly divided into PIH group(n=15) and 3,4-dihydroxya'cetophynone (DHAP)-treated group(n=17). Sixteen nonpregnant women or 15 normal pregnant women served as controls. The concentration of atrial natriuretic polypeptide (ANP) ,cAMP and cGMP in the maternal and fetal(umbilical vein) plasma were measured by using the method of radioimmunoassays. The levels of ANP, cAMP and cGMP in the plasma of normal pregnant women were slightly higher than in the nonpregnant women(P>0. 05). In normal pregnant controls,the contents of ANP and cGMP in the maternal plasma were much higher and the level of cAMP was lower than in the PIH group(P <0 .01). After DHAP treatment, the levels of plasma ANP and CGMP in PIH patients were obviously decreased (P<0. 05), while the cAMP dramatically increased (P<0. 01) as compared with those before DHAP treatment. Compared with normal pregnant controls, the contents of ANP and cGMP in (he fetal plasma were significantly increased(P<0. 05), whereas the level of cAMP reduced in PIH group. After DHAP treatment, the contents of ANP and cGMP in the fetal plasma were dccrcased(P<0.05) ,bul the content of cAMP was sig-nificantly increased(P<0. 01) in PIH group.