胰岛素样生长因子结合蛋白在人类恶性肿瘤中的研究进展

胰岛素样生长因子(insulin—like growth factor，IGF)系统由IGF及其受体和胰岛素样生长因子结合蛋白(insulin-like growth factor binding protein，IGFBP)组成，体内外研究表明，它们调控着细胞的生长和增殖。IGF是一种强力的促细胞分裂素，其作用决定于IGF与其受体的相互作用。IGFBP是由6种与IGF高亲和力结合蛋白组成的家族，不仅具有运载蛋白的功能，而且通过IGF依赖性或非依赖性机制抑制或促进IGF的作用。近年的研究表明，IGFBP与肿瘤的发生、发展密切相关。

Advance on insulin-like growth factor binding protein in human malignant tumors

Insulin-like growth factors, their receptors and insulin-like growth factor binding protein constitutes insulin-like growth factor system. Studies in vivo and vitro suggest that they can regulate cell growth and proliferation. Insulin-like growth factors have a potent mitogenic effects which dependent on interaction between insulin-like growth factors and their receptors. IGFBP family contains six high-affinity members with variable functions and mechanisms of actions. In addition to functioning as simple carrier proteins, IGFBP can inhibit or promote IGFs by IGF-dependent or IGF-independent mechanism. Recent findings show that the IGFBP is correlated with the initiation and progression of tumor growth.