CD44V6和MMP-9蛋白表达与胃癌浸润和转移的关系

目的探讨CD44V6和MMP-9表达与胃癌浸润和转移的相关性。方法收集胃癌手术标本86例,应用免疫组化MaxvisionTM法检测CD44V6和MMP-9在胃癌组织的表达。结果CD44V6和MMP-9的表达与肿瘤细胞分化无关(P>0.05),与浸润深度、淋巴结转移、PTNM分期具有相关性。CD44V6和MMP-9表达存在相关性。结论CD44V6和MMP-9的阳性表达可作为预测胃癌转移潜能的生物学指标,且CD44V6和MMP-9的表达存在相关性,协同表达预示胃癌具有较强的侵袭转移能力,联合检验有望成为预测胃癌淋巴结转移和浸润能力的1种有价值的手段。

The Correlation of CD44V6 and MMP-9 Protein Expression with Invasiveness and Metastasis in Gastric Carcinoma

Objective To explore the relationship between the expression of CD44V6,MMP-9 protein and invasion and metastasis in gastric carcinoma and to investigate the correlation between the expression of CD44V6 and MMP-9 protein.Methods The expression of CD44V6 and MMP-9 protein were detected with MaxvisionTM immunohistochemical method in 86 surgically resected tumor Results There were no significant correlation between CD44V6 and MMP-9 expression tumor size and tumor differentiation (P>0.05),but significant correlation between their expression and invasion and lymph metastasis and PTNM stage.There is a close relationship between expression of MMP-9 and the expression of CD44V6(r=0.385,P<0.01).Conclusion CD44V6 and MMP-9 are useful markers of predicting the metastatic potential of gastric cancer,and detectation of their expression may be useful for evaluating prognosis and guiding treatment.There is a close relationship between the expression of CD44V6 and MMP-9.The result of their coexamination might be useful to predict lymphatic metastasis of gastric cancer.