| 刺五加多糖对异基因骨髓移植小鼠免疫功能重建的影响 |
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| 引用本文： | 谢蜀生,秦凤华,张文仁,龙振洲. 刺五加多糖对异基因骨髓移植小鼠免疫功能重建的影响[J]. 北京大学学报(医学版), 1989, 0(4) |
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| 作者姓名： | 谢蜀生 秦凤华 张文仁 龙振洲 |
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| 作者单位： | 北京医科大学免疫学教研室(谢蜀生，秦凤华，张文仁)，北京医科大学免疫学教研室(龙振洲) |
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| 摘 要： | 本文用抗Thy-1.2单克隆抗体和补体在体外特异地去除C_(57)BL/6(H—2~b)小鼠骨髓中的T细胞,成功地对致死量照射的BALB/c(H—2~d)小鼠进行了异基因骨髓移植。移植后55天,异基因骨髓移植小鼠的免疫功能明显低于正常小鼠。在移植后45天,用每日100mg/kg剂量的刺五加多糖经腹腔连续给药10天,小鼠对胸腺不依赖抗原TNP-Ba的PFC反应以及对ConA和LPS增殖反应均较对照小鼠明显增加,但对胸腺依赖抗原SRBC的PFC反应以及BSA诱导的DTH反应无明显改善。
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| 关 键 词： | 蒯五加多糖 异基因骨髓移植 免疫重建 |
EFFECT OF POLYSACCHARIDE OF ACANTHOPANAX SENTICOSUS (PAS) ON IMMUNOLOGICAL RECONSTITUTION OF ALLOGENEIC BONE MARROW TRANSPLANTATION IN MICE |
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| Affiliation: | Department of Immunology Xie Shusheng |
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| Abstract: | In this communication the anti-Thy-1.2 monoclonal antibody plus complement were used to purge T cells from allogenic bone marrow. The T-cell-depleted allogeaeic bone marrow successfully reconstituted the immunological functions of the lethally irradiated BALB/c mice.On the forty-fifth day after allogeneic bone marrow transplantation the immunologically reconstituted BALB/c mice were injected with PAS at dosage of 100mg/kg/day i.p for 10 days. The PFC response to thymus-independent antigen TNP-Ba and the mitogenic response to ConA and LPS were significantly increased in drug-receiving group but no increase of PFC response to thymus-dependent antigen SRBC and DTK response induced by BSA was observed. |
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| Keywords: | Polysaccharide of Acanthopanax Senticosus Allogeneic bone marrow transplantation Immunological reconstitution |
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