帕罗西汀治疗肠易激综合征

目的 :观察帕罗西汀治疗肠易激综合征(IBS)的疗效与不良反应。方法 :63例有明显抑郁心理障碍的IBS病人随机分成 2组 ,帕罗西汀组 3 2例 (男性 1 4例 ,女性 1 8例 ;年龄 3 4a±s1 0a) ,对照组 3 1例 ,(男性 1 4例 ,女性 1 7例 ;年龄 3 4a± 1 1a) ,2组均给予硝苯地平 1 0mg、洛哌丁胺 2mg、谷维素 2 0mg ,po,tid;帕罗西汀组同时给予帕罗西汀2 0mg,po,qd;疗程为 4wk ,共 2个疗程。结果 :帕罗西汀组治疗wk 4,8末躯体症状严重度评分 (4 .8± 1 .6,3 .8± 1 .4)、抑郁量表评分 (4 0± 5 ,3 8± 7) ,生活质量评分(5 7± 1 3 ,70± 1 6) ,与对照组 (6.1± 2 .0 ,5 .8±2 .4;5 2± 7,49± 4;49± 1 6,5 1± 1 7)比较差异有非常显著意义 (P <0 .0 1 ) ;帕罗西汀组治疗wk4,8末有效率分别为 75 % ,97% ,对照组为 48% ,5 8% ,(P <0 .0 5 )。帕罗西汀组不良反应轻微。结论 :帕罗西汀治疗伴明显抑郁心理障碍的IBS病人疗效显著 ,且较安全

Paroxetine in treating irritable bowel syndrome

AIM: To observe the efficacy and adverse reactions of paroxetine in treating irritable bowel syndrome(IBS). METHODS: Sixty three IBS patients with obvious syndromes of depression were randomly divided into two groups: paroxetine group of thirty two patients( M 14, F 18;age 34 a± s 10 a), control group of thirty one patients( M 14, F 17;age 34 a±11 a). Two groups of all patients received nifedipine 10 mg,loperamide 2 mg and oryzanol 20 mg, po , tid. The paroxetine group of patients also received paroxetine 20 mg, po , qd, all for 4 wk, 8 wk. RESULTS: The scores of IPS, SDS and QQL in paroxetine group and control group after treatment wk 4, 8 were 4.8±1.6, 3.8 ±1.4; 40±5, 38±7; 57±13, 70±16, and 6.1±2.0, 5.8± 2.4 ; 52±7, 49±4; 49±16, 51±17, respectively ( P <0.01). The effective rate of the paroxetine group were 75 % and 97 %, respectively, and that of the control group were 48 % and 58 %, respectively. Significant difference was found between two groups ( P <0.05). The adverse reactions of the former were mild. CONCLUSION: Paroxetine is effective and safe in treating IBS patients with obvious syndromes of depression.