胃左动脉化疗栓塞联合放疗治疗晚期贲门癌30例临床观察

目的探讨动脉化疗栓塞联合放射疗法治疗晚期贲门癌的疗效。方法晚期贲门癌患者67例,随机分为单放组和综合组,综合组30例,放疗前1周行胃左动脉化疗栓塞,然后给予靶区剂量(DT)60~65Gy,6~7周照射;单放组37例,常规放疗DT70Gy/7周,观察患者治疗效果及影像学改善情况,随访4~28月。结果综合组和单放组梗阻症状改善率分别为100%(30/30)及70.3%(26/37)两组差异有统计学意义(P<0.01);X线好转率分别为86.6%(26/30)及70.3%(26/37)(P>0.05);综合组和单放组患者1、2年生存率分别为80%(24/30)及56.8(21/37)(P<0.05),40%(12/30)及29.7(11/37)(P>0.05)。结论动脉化疗栓塞结合放疗是一种治疗晚期贲门癌的有效方法。

Transarterial chemoembolization combined with radiotherapy in treatment of 30 cases with advanced cardiac carcinoma

Objective To investigate the treatment effects of transarterial chemoembolization(TACE) combined with radiotherapy on advanced cardiac carcinoma. Methods Sixty-seven patients with advanced cardiac carcinoma were randomly divided into two groups: 30 patients were treated by TACE plus radiotherapy, the radiation dose was 60-65 Gy,for 6-7 weeks (TACE+R), 37 patients received radical radiotherapy alone(R), the radiation dose was 70 Gy,for 7 weeks. The patients were followed up within 4 to 28 months and the improvements of clinical symptoms and image on barium meal were observed. Results The improvements of clinical symptoms were 100%(30/30) in TACE+R and 70.3%(26/37) in R group, with an obvious difference between those two groups(P< 0.01). The improvements of obstruction on barium meal were 86.6%(26/30) in TACE+R and 70.3%(26/37) in R group (P> 0.05). The 1-,2-year survival rates were 80%(24/30) and 40%(12/30) in TACE+R, 56.8%(21/37) and 29.7%(11/37) in R group, with the difference in 1-year survival rate between those two groups (P< 0.05). Conclusion Radiotherapy combined with TACE was an effective method for advanced cardiac carcinoma.