| 妊娠相关蛋白-A对冠心病易损斑块的预测价值 |
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| 引用本文： | 靳奇峰,王彦富,陈园园,石胜伟,孙景芝,张慧玲,刘燕,吴德光,李清贤.妊娠相关蛋白-A对冠心病易损斑块的预测价值[J].临床心血管病杂志,2012(1):28-30. |
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| 作者姓名： | 靳奇峰 王彦富 陈园园 石胜伟 孙景芝 张慧玲 刘燕 吴德光 李清贤 |
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| 作者单位： | 天津医科大学研究生院;山东省心脏疾病诊疗重点实验室济宁医学院附属医院心内一科;山东大学医学院 |
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| 基金项目： | 山东省自然科学基金项目(No:ZR2010HL032) |
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| 摘 要： | 目的:探讨妊娠相关蛋白A(PAPP-A)与冠心病及斑块易损性之间的关系。方法:选择急性冠状动脉综合征(ACS组)患者20例,稳定性心绞痛(SAP组)患者19例,采用ELISA测定患者血清中PAPP-A水平,同时应用光学相干断层成像技术测定患者斑块纤维帽厚度。结果:ACS组PAPP-A高于SAP组(48.71±18.90)ng/L∶(18.93±11.11)ng/L,P<0.01];ACS组斑块纤维帽厚度低于SAP组(45.44±18.25)μm∶(90.74±24.54)μm,P<0.01]。ACS组中PAPP-A与斑块纤维帽厚度呈负相关,r=-0.778,P<0.01。逐步(Stepwise)多重线性回归分析认定PAPP-A是预测斑块易损性的一种独立危险因素。结论:PAPP-A是一种独立的、能够有效预测冠心病风险以及斑块易损性的标记物。
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| 关 键 词： | 冠心病 妊娠相关蛋白A 光学相干断层成像 易损斑块 纤维帽厚度 |
Pregnancy associated plasma protein-A predicts vulnerable plaque in coronary artery disease |
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| JIN Qifeng,WANG Yanfu,CHEN Yuanyuan,SHI Shengwei,SUN Jingzhi,ZHANG Huiling,LIU Yan,WU Deguang,LI Qingxian.Pregnancy associated plasma protein-A predicts vulnerable plaque in coronary artery disease[J].Journal of Clinical Cardiology,2012(1):28-30. |
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| Authors: | JIN Qifeng WANG Yanfu CHEN Yuanyuan SHI Shengwei SUN Jingzhi ZHANG Huiling LIU Yan WU Deguang LI Qingxian |
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| Institution: | 1Graduate School of Tianjin Medical University,Tianjin,300192,China;2Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment,Unit 1 of Cardiology Department,Affiliated Hospital of Jining Medical College;3School of Medicine,Shandong University) |
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| Abstract: | Objective:To analysis the relationship between pregnancy associated plasma protein-A(PAPP-A) and vulnerable plaque in coronary artery disease.Method:There were 20 cases in ACS group and 19 in SAP group.The levels of PAPP-A were determined by enzyme linked immunosoebent assay(ELISA),and OCT was used to measure the fibrous cap thickness of coronary artery atherosclerotic plaques.Result:The levels of PAPP-A in ACS group were significantly higher than those in SAP group(48.71±18.90]ng/L∶18.93±11.11]ng/L,P<0.01).Fibrous cap thickness of plaques in ACS group were thinker than those in SAP group(45.44±18.25]μm∶90.74±24.54]μm,P<0.01). The levels of PAPP-A(r=-0.778,P<0.01) were correlated negatively with fibrous cap thickness in ACS patients.Gradually(Stepwise) multiple linear regression analysis identified that PAPP-A predicted vulnerability as an independent risk factor.Conclusion:PAPP-A,as an independent and effective marker,can predict the risk of coronary disease and vulnerable plaque. |
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| Keywords: | coronary artery disease pregnancy associated plasma protein-A optical coherence tomography vulnerable plaque fibrous cap thickness |
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