补充微量营养素对2型糖尿病患者感染及血清3-硝基酪氨酸水平的影响

目的观察补充微量营养素对2型糖尿病患者感染发生率及其蛋白质硝基化的影响。方法选取2型糖尿病患者76例,按随机方法分为对照组和干预组,干预组给予微量营养素补充剂,对照组给予安慰剂,每日口服2片,观察时间为6个月。每月随访一次,了解受访者饮食、运动和感染发生情况。研究前后对受访者均进行一般情况的调查、血液生化检查和血清3-硝基酪氨酸水平(3-NT)测定。研究结束后对干预组人群血清3-NT水平与感染发生情况进行回归分析。结果 6例患者退出研究,获得70例有效数据,干预组33例,男性14例(42.4%),女性19例(57.6%);对照组37例,男性14例(37.8%),女性23例(62.2%),两组性别分布差异无统计学意义(χ2=0.15,P0.05)。研究前后受访者一般情况、血糖、糖化血清蛋白、糖化血红蛋白等化学检验指标及平均每日能量及各营养素摄入量,轻体力运动时间两组之间差异均无统计学意义(P0.05)。研究期间受访者的发热率、发热时体温、发热持续天数、皮肤脓肿与破溃发生率、阴道炎或尿路感染发生率、胆囊炎和牙龈炎发生率干预组低于对照组,差异有统计学意义(P0.05)。研究结束时干预组血清3-NT水平显著低于对照组,差异有统计学意义(P0.05)。回归分析结果显示进入回归方程的有发热及其持续情况,皮肤脓肿与破溃、牙龈炎四项指标(P0.05),其中关系最密切的指标是发热情况(β=0.541,P=0.027)。结论补充微量营养素可降低2型糖尿病患者感染发生率,并降低其蛋白质硝基化水平。

Effects of Supplementation of Micronutrients on Incidences of Common Infections and Serum 3-nitrotyrosine in Type 2 Diabetic Patients

Objective To obverse the effects of supplementation of micronutrients on incidences of common infections and serum 3-nitrotyrosine in patients with type 2 diabetes. Methods A randomized double blind and placebo-control trial was carried out, in which 76 type 2 diabetic patients were enrolled and randomized to tablets of micronutrients and placebo, respectively for 6 months. Records of diet, exercise and infection were made every month during the study. Common characteristics, blood biochemical variables and...