改良化疗方案治疗难治复发性白血病毒副反应的护理

改良的FLAG[氟达拉宾(fludambine) 阿糖胞苷(arabinosyl cytosine) 粒细胞集落刺激因子(G-CSF)，简称FLAG]方案即应用标准剂量阿糖胞苷及在化疗前不用粒细胞集落刺激因子，用以治疗难治与复发性白血病33例，有效率为70％。其主要毒副反应为强烈的骨髓抑制及免疫抑制，化疗后第2周为预防各种并发症的关键时期，此时白细胞、血小板均为最低值，应密切观察体温的变化，认真查体，及时发现感染灶，配合医生给予强有力的支持治疗及保护性隔离，加强饮食宣教及皮肤护理，可提高病人的生存质量。

Nursing care of side effect by modified FLAG regimen in the treatment of refractory and recurrent leukemia

Modified FLAG regimen refers to the therapy with standard dose fludarabine and cytarabine but without Granulocyte colony stimulation factor (G-CSF) before chemotherapy. We applied the regimen in the treatment of 33 cases of refractory and recurrent leukemia, the total curative effectiveness rate reaching 70%. The side effects included intensive bone marrow depression and immunodepression. The second week following the chemotherapy was the key period since the white blood cell and platelet count went down to their lowest level. During this period, the nursing measures mainly involved in close observation of patient's body temperature, careful conduct of physical examination, timely finding of infectious foci, more collaboration with doctors in intensifying supporting therapy and protective insulation of patients, enhancement of diet instructions and skin care, all of which contributed more to the raise of patient's quality of life.