| CD4~+CD25~+调节性T细胞在类风湿性关节炎中的研究进展 |
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| 引用本文： | 王婷玉,李俊.CD4~+CD25~+调节性T细胞在类风湿性关节炎中的研究进展[J].中国药理学通报,2008,24(11). |
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| 作者姓名： | 王婷玉 李俊 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032 |
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| 摘 要： | CD4+CD25+调节性T细胞(CD4+CD25+Tregs)主要发挥抑制性免疫调节功能,在维持外周免疫耐受和预防自身免疫性疾病中发挥重要作用。该文综述了CD4+CD25+Tregs的特征、作用机制及其在类风湿性关节炎(RA)中的作用,以便进一步研究此群细胞的功能,为RA的防治提供新的思路。
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| 关 键 词： | 类风湿性关节炎 CD25 抑制 调节性T细胞 |
Progress of CD4~+CD25~+ regulatory T cells in rheumatoid arthritis |
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| WANG Ting-yu,LI Jun.Progress of CD4~+CD25~+ regulatory T cells in rheumatoid arthritis[J].Chinese Pharmacological Bulletin,2008,24(11). |
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| Authors: | WANG Ting-yu LI Jun |
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| Institution: | WANG Ting-yu,LI Jun(School of Pharmacy,Anhui Medical University,Hefei 230032,China) |
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| Abstract: | CD4+CD25+ regulatory T cells(CD4+CD25+Tregs),a suppressor T cell population,have been shown to play an important role in maintaining peripheral tolerance and the prevention of autoimmunity.This review summarizes the characteristics and mechanism,as well as their role in rheumatoid arthritis(RA).An understanding of these issues is likely to facilitate the development of CD4+CD25+Tregs-cell-based therapies for the treatment of RA. |
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| Keywords: | CD25 |
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