Morbidity and immune response to natural schistosomiasis in baboons (<Emphasis Type="Italic">Papio anubis</Emphasis>) |
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Authors: | Idle?Farah Andreas?B?rjesson Thomas?Kariuki Dorcas?Yole Mbaruk?Suleman Jann?Hau Email author" target="_blank">Hans-Erik?CarlssonEmail author |
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Institution: | (1) Division of Comparative Medicine, Department of Neuroscience, Uppsala University, BMC Box 572, 751 23 Uppsala, Sweden;(2) Division of Infectious Diseases, Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya;(3) Present address: National Museums of Kenya, Nairobi, Kenya;(4) Present address: Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya |
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Abstract: | The morbidity and immunological response to naturally acquired Schistosoma mansoni infection in a population of wild baboons (n=28) was investigated. Serum obtained from the baboons was assayed for adult worm (SWAP) and schistosome egg (SEA)-specific immunoglobulin (Ig)G and IgM antibodies. The animals were euthanised, perfused to recover adult schistosome worms and schistosome-related pathology was assessed. Nineteen animals (68%) had high serum levels of SWAP-specific IgG antibodies and 15 (54%) had high levels of SEA-specific IgG antibodies. Nine animals (32%) had high levels of SWAP-specific IgM antibodies and six (21%) had high levels of SEA-specific IgM antibodies. Mild schistosome-related pathology was noted in 18 animals (64%). However, adult schistosome worms were recovered from only three animals (10%). The results indicate a high exposure to schistosomiasis for free-ranging baboons inhabiting an endemic area, as evidenced by the high prevalence of parasite-specific humoral antibody response. However, this high exposure is associated with low worm recovery and mild pathology. In addition, parasite-specific IgM antibodies provided a good indicator of an active schistosome infection. |
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