| 抗氧化剂对染尘大鼠血液中抗氧化酶活性的影响 |
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| 引用本文： | 米术斌,马春虎,王芳,刘艳荣,张艳淑. 抗氧化剂对染尘大鼠血液中抗氧化酶活性的影响[J]. 承德医学院学报, 2005, 22(4): 292-295 |
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| 作者姓名： | 米术斌 马春虎 王芳 刘艳荣 张艳淑 |
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| 作者单位： | 承德医学院,河北,承德,067000;承德医学院附属医院;华北煤炭医学院 |
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| 摘 要： | 目的:探讨抗氧化剂茶多酚(TP)联合维生素C(VitC)、维生素E(VitE)对染尘大鼠血液中抗氧化酶活性的影响.方法:40只雄性Wistar大鼠随机分为5组:对照组、石英粉尘组(SiO2组)、TP组、TP VitC组和TP VitE组,每组均为8只.分别检测各组大鼠血液中一氧化氮(NO)、一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活性和丙二醛(MDA)的含量.结果:TP联用VitC、VitE可明显降低染尘大鼠血液中NO、MDA及NOS的活性及显著提高染尘大鼠血液中SOD、GSH-Px的活性(与SiO2组比较均有显著差异:P<0.05).结论:茶多酚联合维生素C、维生素E对石英粉尘引起的氧化损伤具有较好的抑制作用.
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| 关 键 词： | 石英粉尘 茶多酚 氧化损伤 抗氧化酶 |
| 文章编号： | 1004-6879（2005）04-0292-04 |
| 收稿时间： | 2004-10-24 |
| 修稿时间： | 2004-10-24 |
EFFECTS OF ANTIOXIDANT ON ANTIOXIDASE ACTIVITY IN BLOOD OF SILICOTIC RATS |
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| MI Shu-bin, WANG Fang, LIU Yan-rong, et al. EFFECTS OF ANTIOXIDANT ON ANTIOXIDASE ACTIVITY IN BLOOD OF SILICOTIC RATS[J]. Journal of Chengde Medical College, 2005, 22(4): 292-295 |
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| Authors: | MI Shu-bin WANG Fang LIU Yan-rong et al |
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| Affiliation: | Chengde Medical College, Hebei Chengde 067000, China |
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| Abstract: | Objective:To investigate the effects of tea polyphenols(TP) combined with vitamin C and vitamin E on antioxidase activity in blood of silicotic rats.Methods:40 male Wistar rats were used and randomly divided into five groups: control group,silica(SiO_2) group,TP group,TP+VitC group and TP+VitE group.Each group had 8 rats.The activity of NO,MDA,NOS,SOD and GSH-Px in blood were detected respectivly.Results:TP combined with vitamin C,vitamin E could decrease the NO,MDA,NOS activity and increase the SOD,GSH-Px activity in blood of silicotic rats significantly(compared with SiO_2 group:<0.05).Conclusions:TP combined with Vit C,Vit E has certain inhibitory effects on oxidative damages induced by silica dust. |
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| Keywords: | Silica dust Tea polyphenols Oxidative damage Antioxidase |
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