| 长链非编码RNA与肿瘤研究进展 |
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| 引用本文： | 朱雯.长链非编码RNA与肿瘤研究进展[J].中国肿瘤临床,2012,39(8):476-480. |
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| 作者姓名： | 朱雯 |
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| 作者单位： | ①.南京医科大学第一临床医学院临床医学系(南京市210029) |
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| 基金项目： | 本文课题受江苏省自然科学基金,江苏省"六大人才高峰"计划项目 |
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| 摘 要： | 在基因组中大量转录的长链非编码RNA, 因其在致癌与肿瘤抑制途径中显露出的潜在作用而成为肿瘤研究的新热点。虽然这些新基因在各种人类肿瘤中普遍异常表达, 但其中大部分的生物学功能仍未可知。近年来, 许多研究显示长链非编码RNA, (Long non-coding RNAs, LncRNAs)与肿瘤的发生、发展密切相关。本文结合国内外最新报道, 对LncRNAs在各种肿瘤中的研究进展作一综述。
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| 关 键 词： | 长链非编码RNA 肿瘤 肿瘤发生 |
| 收稿时间： | 2011-08-25 |
Research Progress of Long Non-coding RNAs in Human Carcinomas |
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| Wen ZHU.Research Progress of Long Non-coding RNAs in Human Carcinomas[J].Chinese Journal of Clinical Oncology,2012,39(8):476-480. |
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| Authors: | Wen ZHU |
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| Institution: | ①.Department of Clinical Medicine, The First Medical College of Nanjing Medical University, Nanjing 210029, China②.Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China |
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| Abstract: | Long non-coding RNAs (LncRNAs) found to be pervasively transcribed in the genome are emerging as new players in the cancer paradigm. LncRNAs demonstrate potential roles both in oncogenic and tumor suppressive pathways. Although these novel genes are frequently aberrantly expressed in various human cancers, the biological functions of the vast majority remain unknown. Re- cently, evidence proving the significant relationship between LncRNAs with tumorigenesis and development has started to accumulate. This review summarizes the recent progress, both domestic and overseas, in research on specific LncRNAs in human carcinomas. |
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