CD105和VEGF在水泡状胎块中的表达及意义

  目的  研究CD105及VEGF在水泡状胎块（hydatidiform mole,HM）与水肿性流产（hydropic abortus,HA）绒毛滋养细胞中的表达差异及意义。  方法  采用免疫组织化学S-P法分别检测20例正常妊娠（normal pregnancy,NP）,30例HA,20例部分性水泡状胎块（partial hydatidiform mole,PHM）和20例完全性水泡状胎块（complete hydatidiform mole,CHM）的绒毛滋养细胞中CD105和VEGF的表达水平。  结果  1）CD105在HM中阳性表达率明显高于HA和NP,差异有统计学意义（P < 0.05）;2）VEGF在HM中阳性表达率低于HA和NP,差异有统计学意义（P < 0.05）;3）经Spearman等级相关检验,CD105和VEGF在HA与HM中表达呈负相关（r=-0.447,P < 0.05）。  结论  在HM绒毛滋养细胞中,VEGF的表达下降与CD105的表达增强可能在滋养细胞增殖与侵袭作用中起着一定作用。CD105和VEGF可作为标记绒毛滋养细胞的免疫组织化学标记物,用于HM和HA的鉴别诊断。 

Expression and Significance of CD105 and VEGF in Hydatidiform Mole

  Objective  To research the different expression and significance of CD105 and vascular endothelial growth factor (VEGF) in villous trophoblast between hydatidiform mole (HM) and hydropic abortus (HA).  Methods  Immunohistochemical SP method was used to detect the expression level of CD105 and VEGF in villous trophoblast with 20 cases of normal pregnancy (NP), 30 cases of HA, 20 cases of partial hydatidiform mole (PHM) and 20 cases of complete hydatidiform mole (CHM).  Results  The expression rates of CD105 in HM were significantly higher than those in HA and NP, the differences were statistically significant (P < 0.05). The expression rates of VEGF in HM were lower than those in HA and NP, the differences were statistically significant (P < 0.05). The result of Spearman correlation test showed a negative correlation between CD105 and VEGF expression in HM and HA (r = - 0.447, P < 0.05).  Conclusion  The decreased expression of VEGF and the increased expression of CD105 may be associated with the proliferation and invasion of the villous trophoblast in HM. CD105 and VEGF can be used as immunohistochemcial markers of villous trophoblasts for differential diagnosis of HM and HA.