Adipose tissue expression of IL-18 and HIV-associated lipodystrophy |
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| Authors: | Lindegaard Birgitte Hansen Ann-Brit Eg Pilegaard Henriette Keller Pernille Gerstoft Jan Pedersen Bente Klarlund |
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| Affiliation: | Department of Infectious Diseases, University of Copenhagen, Copenhagen, Denmark. |
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| Abstract: | IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy. |
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