| 《中华放射医学与防护杂志》创办者之一姚家祥(1922—2021) |
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| 引用本文： | 本刊编辑部.《中华放射医学与防护杂志》创办者之一姚家祥(1922—2021)[J].中华放射医学与防护杂志,2022,42(2):88-88. |
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| 作者姓名： | 本刊编辑部 |
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| 基金项目： | 山东省医药卫生科技发展计划项目（202012070680）；山东省自然科学基金面上项目（ZR2021MH053）；山东省自然科学基金青年基金项目（ZR2020QC082）；国家自然科学基金青年科学基金项目（32100999） |
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| 摘 要： | 《中华放射医学与防护杂志》的创办者之一、中国疾控中心辐射安全所姚家祥研究员因病医治无效，于2021年12月23日上午7点40分逝世，享年100岁。
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| 关 键 词： | 电离辐射 介入手术 儿童 双着丝粒染色体 |
| 收稿时间： | 2021/9/22 0:00:00 |
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| Abstract: | Objective To evaluate the effect of ionizing radiation on chromosome aberration of peripheral blood lymphocytes in children with vascular interventional surgery. Methods The chromosome aberration of peripheral blood lymphocytes was analyzed before and after vascular interventional surgery to assess the effect of low-dose ionizing radiation on chromosomes. Peripheral blood (PB) was collected using heparin as an anticoagulant from 26 patients before and after (within 10 minutes) vascular interventional surgery (Informed consent was obtained from the patients'' parents). Results Dicentric + centric ring (dic+r) formation increased significantly (U=647, P<0.01) in peripheral blood lymphocytes of children after interventional surgery. No correlation was observed between the rate of dic+r and the cumulative dose (CD), dose area product (DAP), age, body weight, gender and the estimated effective dose (P>0.05). There was no significant difference in dic+r rate of children between different genders, ages and lesion sites (P>0.05). The dic+r rate after interventional operation exceeded 40×10-3 in 4 of 26 cases and one of them was as high as 95.83×10-3. Conclusions The ionizing radiation during children''s vascular interventional surgery can lead to the increase of chromosome aberration of peripheral blood lymphocytes and some children are abnormally sensitive. Great attention should be paid to the justification and radiation protection during interventional surgery for children. |
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| Keywords: | Ionizing radiation Interventional operation Children Dicentric chromosome |
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