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Association of plasma osteopontin levels with coronary calcification evaluated by tomographic coronary calcium scoring
Authors:Muhammedullah Aryan  Alper Kepez  Enver Atalar  Tuncay Hazirolan  ?brahim Haznedaroglu  Deniz Akata  Necla Ozer  Serdar Aksoyek  Kanan Ovunc  Ferhan Ozmen
Institution:(1) Cardiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey;(2) Cardiology Clinic, Eskisehir Yunus Emre State Hospital, Uluonder Mah, Salih Bozok Cad. No. 23, Eskisehir, 26190, Turkey;(3) Radiology Department, Faculty of Medicine, Hacettepe University, Ankara, Turkey;(4) Internal Medicine Department, Division of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Abstract:Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of coronary calcification. The aim of the present study is to evaluate the association between plasma osteopontin (OPN) levels and coronary calcification quantified by using tomographic coronary calcium scoring. Plasma OPN levels were measured from samples of 80 intermediate-risk asymptomatic patients (56 ± 10 years) who underwent tomographic coronary calcium scoring via multislice computed tomography for incremental risk stratification. There was no significant difference regarding OPN levels between patients with and without coronary calcification in the whole study population. Of 49 patients not receiving renin–angiotensin system inhibitors and/or statins, plasma OPN levels of patients with coronary calcification (38.7%) were significantly higher than those without coronary calcification (61.3%) (8.88 ± 2.85 vs. 6.79 ± 2.41, P = 0.008, respectively). On a binary logistic regression model, only age and plasma OPN level were found to be significant independent associated variables for the presence of coronary calcification in patients not receiving these medications (odds ratio for age, 1.15, P = 0.017; for plasma OPN levels, 1.63, P = 0.014). Our results indicate that plasma OPN levels may be predictive of coronary calcification, suggesting an important role of OPN in the atherosclerotic calcification pathogenesis.
Keywords:Osteopontin  Coronary atherosclerosis  Coronary calcification
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