| 调强放疗联合NP方案同步与序贯治疗中晚期非小细胞肺癌的疗效观察 |
| |
| 引用本文： | Xiaodong Jiang Da''''an Song Weiming Zhang Jin Wu. 调强放疗联合NP方案同步与序贯治疗中晚期非小细胞肺癌的疗效观察[J]. 中德临床肿瘤学杂志, 2007, 6(1): 2-4. DOI: 10.1007/s10330-006-0020-1 |
| |
| 作者姓名： | Xiaodong Jiang Da''''an Song Weiming Zhang Jin Wu |
| |
| 作者单位： | Department of Radiotherapy, First People＇s Hospital of Lianyungang, Lianyungang 222002, China |
| |
| 基金项目： | Supported by a grant from Health Bureau of Lianyungang City＇s Fund Program （No. 05051）. |
| |
| 摘 要： | Objective： To evaluate the clinical effects of concurrent and sequential therapy for middle and advanced stage non-small cell lung cancer （NSCLC） useing IMRT combined with NP regimen chemotherapy. Methods： Eighty patients with middle and advanced stage NSCLC were randomized into two groups. Forty patients were underwent sequential therapy and other 40 patients were underwent concurrent therapy. IMRT was used in radiotherapy and NP regimen of vinorelbine＋cispatin （NP） was used in chemotherapy. Results： （1） The overall response （CR＋PR） rate was 75% in concurrent group and 45% in sequential group （P〈0.05）; （2） The treatment courses were 84 days and 140 days for concurrent group and sequential group respectively （P〈0.05）; （3） One-year survival rate in concurrent group was 72.4% and 52.3% in sequential group respectively; （4） The toxic effects can be tolerable by all of patients. Conclusion： The concurrent chemo-radiotherapy has better overall response, one-year survival rate and shorter treatment course than the sequential chemo-radiotherapy, so it is a better method for the treatment of middle and advanced stage NSCLC, but the long term survival rate will be studied.
|
| 关 键 词： | 中晚期 非小细胞肺癌 适形调强放疗 NP方案化疗 同期联合治疗 序贯治疗 临床研究 |
| 收稿时间： | 2006-11-03 |
| 修稿时间： | 2006-11-25 |
Clinical study on concurrent and sequential therapy of intensity modulated radiation therapy (IMRT) combined with NP regimen chemotherapy in the treatment of middle and advanced non-small cell lung cancer |
| |
| Xiaodong Jiang,Da’an Song,Weiming Zhang,Jin Wu. Clinical study on concurrent and sequential therapy of intensity modulated radiation therapy (IMRT) combined with NP regimen chemotherapy in the treatment of middle and advanced non-small cell lung cancer[J]. The Chinese-German Journal of Clinical Oncology, 2007, 6(1): 2-4. DOI: 10.1007/s10330-006-0020-1 |
| |
| Authors: | Xiaodong Jiang Da’an Song Weiming Zhang Jin Wu |
| |
| Affiliation: | (1) Department of Radiotherapy, First People’s Hospital of Lianyungang, Lianyungang, 222002, China |
| |
| Abstract: | Objective: To evaluate the clinical effects of concurrent and sequential therapy for middle and advanced stage non-small cell lung cancer (NSCLC) useing IMRT combined with NP regimen chemotherapy.Methods: Eighty patients with middle and advanced stage NSCLC were randomized into two groups. Forty patients were underwent sequential therapy and other 40 patients were underwent concurrent therapy. IMRT was used in radiotherapy and NP regimen of vinorelbine cispatin(NP) was used in chemotherapy. Results: (1) The overall response (CR PR) rate was 75% in concurrent group and 45% in sequential group (P＜0.05); (2) The treatment courses were 84 days and 140 days for concurrent group and sequential group respectively (P＜0.05); (3) One-year survival rate in concurrent group was 72.4% and 52.3% in sequential group respectively;(4) The toxic effects can be tolerable by all of patients. Conclusion: The concurrent chemo-radiotherapy has better overall response, one-year survival rate and shorter treatment course than the sequential chemo-radiotherapy, so it is a better method for the treatment of middle and advanced stage NSCLC, but the long term survival rate will be studied. |
| |
| Keywords: | non-small cell lung cancer (NSCLC) intensity modulated radiation therapy (IMRT) chemotherapy concurrent therapy sequential therapy |
| 本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录！ |
