铜绿假单胞菌对常用抗菌药物的耐药性分析

目的了解铜绿假单胞菌对常用抗菌药物的耐药性，为临床合理用药提供依据。方法采用琼脂纸片扩散法（K—B法）进行药敏试验。结果铜绿假单胞菌对亚胺培南、头孢哌酮／舒巴坦、丁胺卡那霉素的耐药率较低，分别为12．7％、22．8％和30．5％；对氨苄西林、氨苄西林／舒巴坦、复方新诺明、头孢唑啉的耐药率较高，分别为100.0％、99．2％、97．3oA和92．3％。结论临床医生应依据药敏试验结果合理使用抗菌药物，从而减少或避免耐药菌株的增加。

Analysis of drug resistance of Pseudomonas aeruginosa to commonly used antibacterial agents

Objective To investigate the drug resistance of Pseudomonas aeruginosa to commonly used antibacterial agents,and to provide evidence for rational use of antibacterial agents. Methods Disc agar diffusion method （Kirby-Bauer method） was applied to performing drug susceptibility test. Results The drug resistant rate of Pseudomonas aeruginosa was the lowest to imipenem followed by cefoperazone/sulbactam and amikacin （12.7%, 22.8 % and 30.5% respectively）. The drug resistant rate of Pseudomonas aeruginosa was the highest to ampicillin followed by ampicillin/sulbactam, sulfamethoxazole/trimethoprim and cefazolin （ 100.0 %, 99.2 %, 97.3 % and 92.30% respectively）. Conclusion Clinicians should use antibiotics rationally according to the results of drug sensitive tests so as to decrease or prevent accrescence of drug resistant strains.