| 缺血及再灌注损伤中心肌组织钙调蛋白及环磷酸腺苷的变化 |
| |
| 引用本文： | 邢红,王孝铭.缺血及再灌注损伤中心肌组织钙调蛋白及环磷酸腺苷的变化[J].哈尔滨医科大学学报,1990,24(5):422-423. |
| |
| 作者姓名： | 邢红 王孝铭 |
| |
| 作者单位： | 哈尔滨医科大学病理生理学教研室
(邢虹，王孝铭)，哈尔滨医科大学病理生理学教研室(张国义) |
| |
| 摘 要： | 心肌细胞内大量Ca~(2+)聚集是心肌缺血及再灌注损伤的共同途径,是造成细胞不可逆性损伤的主要原因。钙调蛋白(CaM)和环磷酸腺苷(cAMP)均可通过增强肌浆网(SR)的Ca~(2+)摄取及加强肌膜的Ca~(2+)内流等方式调节
|
| 关 键 词： | 钙调蛋白 心肌 缺血 环磷酸腺苷 |
Changes of Calmodulin and cAMP in Rabbit Myocardium During Ischemia and Reperfusion Injury |
| |
| Xing Hong et al.Changes of Calmodulin and cAMP in Rabbit Myocardium During Ischemia and Reperfusion Injury[J].Journal of Harbin Medical University,1990,24(5):422-423. |
| |
| Authors: | Xing Hong |
| |
| Institution: | Department of Pathophysiology |
| |
| Abstract: | This study was performed on rabbits to examine the changes of calmodulin (CAM) and cAMP in the myocardium during ischemia and reperfusion by radioimmunoassy method. The result showed the levels of CaM and cAMP increased at 20 min of ischemia. Both of them were unchanged at 40min of ischemia as compared with the changes at 20 min. The situation was different during reperfusion at different time of ischemia. On the basis of 20 min ischemia, reperfu sion for 10 min decreased the content of CaM, but the content of cAMP was increased, whereas on the basis of 40 min ischemia, reperfusion induced opposite changes: CaM increased, cAMP decreased. |
| |
| Keywords: | Calmodulin cAMP Ischemia/reperfusion injury Heart |
| 本文献已被 CNKI 维普 等数据库收录！ |
