解脲支原体基因群与非淋菌性尿道(宫颈)炎相关性研究

目的:探讨解脲支原体(Uu)基因群与非淋菌性尿道(宫颈)炎NGU(MPC)]的相关性。方法:采用病例对照研究,收集单纯Uu阳性的性病门诊NGU(MPC)患者和非NGU(MPC)就诊者尿道拭子/宫颈拭子标本,通过培养法和PCR法检测Uu及基因分群。结果:共收集标本137例。男性组Uu基因群1占24.3%(18/74),基因群2占59.5%(44/74),基因群1,2同时阳性6.8%(5/74);女性组Uu基因群1占38.1%(24/63),基因群2占54%(34/63),基因群1,2同时阳性7.9%(5/63)。男女性别中Uu分布均以基因群2为主,Uu基因群1,2在男性NGU组与非NGU组间、女性MPC组与非MPC组间的分布没有统计学差异(P均>0.05)。结论:不同基因群Uu在尿道(宫颈)炎患者与非尿道(宫颈)炎就诊者之间的分布无差异,提示与非淋菌性尿道(宫颈)炎无相关性。

Studay on the Association of Gene Cluster of Ureaplasma Urealyticum with Nongonococcal Urethritis/Cervicitis

Objective:To assess the association of U.urealyticum gene clusters 1 and 2 with nongonococcal urethritis/cervicitis. Methods:Urethral/cervical samples were collected from patients with and without non-gonococcal urethritis/cervicitis.U.urealyticum were detected by culture and gene clusters were classified by PCR.(Results): 173 samples were collected totally.Gene cluster 2 were dominant among the 173 samples:59.5% samples from male and 54% from female patients were gene cluster 2 positive.There were no statistically significance in the prevalence rate of Uu gene clusters 1 and 2 between the urethritis/cervicitis and the non-urethritis/cervicitis group.Conclusion:This study suggested that gene clusters of U.urealyticum were unlikely to(associated) with the development of NGU/MPC.