5-氨基酮戊酸光动力疗法治疗鲍温病10例疗效观察

目的观察5-氨基酮戊酸光动力疗法治疗鲍温病的临床疗效。方法将20例鲍温病患者分为两组,各10例。治疗组予5-氨基酮戊酸外涂于皮损处,3h后予红光照射20min,能量密度100～120J/cm2,1次/周,共4周。对照组外涂5-氟尿嘧啶软膏皮损处,2次/d,共4周。结果治疗组完全缓解率为90.00%,对照组为30.00%,两组间完全缓解率比较,差异有统计学意义(P<0.05)。且治疗组均未见严重不良反应,对照组有溃疡及瘢痕等不良反应。结论 5-氨基酮戊酸光动力疗法治疗鲍温病临床疗效较好,且无严重不良反应,值得临床推广应用。

Clinical Effect of 5-aminolevulinic Acid Photodynamic Treating 10 Cases Bowen' s Disease

Objective To observe the clinical effect of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) treating Bowen’s disease.Methods Twonty cases of Bowen’s disease were randomly divided into treatment group and control.Each group has 10 cases.Treatment group:applied 5-aminolevulinic acid(ALA) to the skin lesions,3 hours later red light irradiated 20min,energy density was 100~120 J/cm2,one time a week for 4 weeks.Control group:smearing 5-fluorouracil cream(5-Fu ointment) on skin lesions,twice daily for 4 weeks.Results Completely remission rate was 90.00% in treatment group and 30.00% in control.The difference between them had statistical significance(P<0.05).There were no serious side effects in the treatment group,but the control group appeared ulcer,scar and other side effects.Conclusion 5-aminolevulinic acid photodynamic is a good therapeutic method for Bowen’s disease.