| 抗CCP、RF检测中国人群类风湿性关节炎诊断试验Meta分析 |
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| 引用本文： | 谢诗涓 李健 李乐峰. 抗CCP、RF检测中国人群类风湿性关节炎诊断试验Meta分析[J]. 中国骨质疏松杂志, 2012, 18(1): 12-16. DOI: 10.3969/j.issn.1006-7108.2012.01.004 |
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| 作者姓名： | 谢诗涓 李健 李乐峰 |
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| 作者单位： | 怀化市第一人民医院骨三科,湖南怀化,418000 |
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| 摘 要： | 目的 采用诊断试验Meta分析综合评价抗环瓜氨酸肽抗体(CCP)和血清学指标类风湿因子(RF)筛查类风湿性关节炎(RA)的效果.方法 通过检索万方、维普、CNKI等数据库,获得有关抗CCP和RF诊断筛查RA的文献,提取相关数据；采用DPS6.5进行诊断试验Meta分析.结果 抗CCP的综合准确度为0.831,诊断优势比为24.154；RF的综合准确度为0.765,诊断优势比为10.540；抗CCP的诊断准确度高于RF(P＜0.01).结论 抗CCP诊断RA能获得较好的特异度,而RF诊断RA能获得较好的灵敏度;若能联合抗CCP和RF,对RA具有较高的诊断价值.
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| 关 键 词： | 类风湿性关节炎 抗环瓜氨酸肽抗体 类风湿因子 Meta分析 |
Meta-analysis of anti-CCP and RF measurement for the diagnosis of rheumatoid arthritis in Chinese |
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| XIE Shijuan??LI Jian??LI Lefeng. Meta-analysis of anti-CCP and RF measurement for the diagnosis of rheumatoid arthritis in Chinese[J]. Chinese Journal of Osteoporosis, 2012, 18(1): 12-16. DOI: 10.3969/j.issn.1006-7108.2012.01.004 |
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| Authors: | XIE Shijuan??LI Jian??LI Lefeng |
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| Affiliation: | .Department of Orthopedics,The First People’s Hospital of Huaihua,Hunan 418000,China |
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| Abstract: | Objective To comprehensively assess the efficacy of anti-CCP and RF in rheumatoid arthritis(RA) screening using Meta-analysis.Method The papers related to anti-CCP and RF in RA screening were searched in Wanfang,Weipu,CNKI databases and the relative date was acquired.Meta-analysis was conducted using DPS 6.5 software.Results The TPR of anti-CCP was 0.831 and diagnostic OR was 24.154.The TPR of RF was 0.765 and diagnostic OR was 10.540.The accuracy of anti-CCP was much higher than RF(P<0.01).Conclusion The specificity of anti-CCP is higher than that of RF.However,the sensitivity of RF is higher than that of anti-CCP.The combination of RF and anti-CCP has meaningful value for the diagnosis of RA. |
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| Keywords: | Rheumatoid arthritis anti-cyclic citrullinated peptide antibody(Anti-CCP) Rheumatoid factor(RF) Meta analysis |
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