免疫球蛋白和补体与白癜风发病的相关性研究

目的探讨免疫球蛋白和补体与白癜风发病的关系。方法采用免疫散射比浊法检测120例白癜风患者血清免疫球蛋白IgG、IgA、IgM和补体C3、C4水平,根据不同分型分为4组,并以60例正常人作为对照组进行比较。结果白癜风组血清补体C3水平低于对照组,差异有统计学意义(P<0.01),IgG、IgA、IgM和C4水平与对照组比较,差异均无统计学意义(P>0.05)。不同类型的白癜风患者血清IgG、IgA、IgM、C3和C4水平比较,差异均无统计学意义(P>0.05)。结论白癜风的发病与体液免疫有一定的关系。

Correlation of Immunoglobulins and Complements with the Pathogenesis of Vitiligo

Objective To investigate the correlation of serum immunoglobulins and complements with the pathogenesis of vitiligo.Methods The serum levels of IgG,IgA,IgM,C3,and C4 in 120 patients with vitiligo were determined by immunoturbidimetry and then compared with those in 60 healthy cases.These 120 vitiligo patients were also divided into four groups according to their subtypes,and the serum levels of the above items were compared inter-groups.Results The serum C3 level in patients with vitiligo was significantly lower than that in the healthy controls(P<0.01).The serum levels of IgG,IgA,IgM,C3,and C4 showed no significant difference among four groups with different subtypes of vitiligo(all P>0.05).Conclusion The pathogenesis of vitiligo is associated with the humoral immunity to some extent.