首发精神分裂症代谢综合征的病例对照研究

目的探索精神分裂症与代谢综合征(MS)之间的关系。方法选择符合美国《诊断与统计手册： 精神障碍》(DSM)-Ⅳ诊断标准的首发精神分裂症患者231 例(病例组)，同时从社区选取年龄和性别配比的普通社区健康居民63 例(对照组)。所有研究对象均检测身高、体重、腰围、空腹血糖(FPG)、血脂和血压，采用国际糖尿病联盟(IDF)2005 年MS 标准诊断MS。结果病例组FPG和总胆固醇(TC)水平均显著高于对照组(P<0.001)；病例组MS 检出率(17.4%)高于对照组(4.76%) (P=0.021)。结论首发精神分裂症患者在早期即可出现糖脂代谢的异常，精神分裂症与MS 可能存在某种关联。

Relationship between First-episode Schizophrenia and Metabolic Syndrome: a Case-control Study

Objective To explore the relationship between first-episode schizophrenia and metabolic syndrome(MS).Methods 231 first-episode schizophrenia patients(schizophrenia group) and 63 healthy controls(healthy group) were selected to detect the height,weight,waistline,fasting plasma glucose(FPG),blood lipid and blood pressure.International Diabetes Federation(IDF) MS Diagnostic Criterion(2005) was used to diagnose MS.Results The FPG and Total Cholesterol(TC) of the schizophrenia group were significantly higher than the control group(P<0.001).The MS detection rate in the schizophrenia group was higher than in the control group(P=0.021).Conclusion First-episode schizophrenia patients could have glucose-lipid metabolism disorder during the early stage.