先天性胆道闭锁肝内毛细胆管超微结构与临床预后关系探讨

目的　探讨先天性胆道闭锁 (CBA)肝内毛细胆管超微结构与临床预后的关系。方法　用PHILIPSCM10透射电镜观察肝内毛细胆管超微结构 ,比较肝组织电镜切片中发育良好与发育不良的毛细胆管数目 ,并与临床预后作比较。结果　 2 5例CBA患儿中 ,肝内毛细胆管发育良好为主的 13例 ,其中 12例术后生存 ,生存率为 92 3% (12 / 13) ;毛细胆管发育不良为主的 12例中 ,仅有 4例生存 ,生存率为 33 3% (4 / 12 ) ,两组生存率有显著性差异 (P <0 0 5 )。结论　肝内毛细胆管的发育情况可作为初步判断术后临床预后指标之一。

Ultrastructure of intrahepatic biliary canaliculi and prognosis of congenital biliary atresia

To investigate the relationship between the ultrastructure of intrahepatic biliary canaliculi and the prognosis of congenital biliary atresia Methods Liver biopsies from 25 patients who were operated on for congenital biliary atresia were examined under the transmission electron microscope The relationship between the number of well developed bile canaliculi and patient prognosis was studied Results The survival rate for 13 patients with well developed intrahepatic biliary canaliculi and 12 patients with poorly developed intrahepatic biliary canaliculi were 92 3% (12/13) and 33 3% (4/12) respectively The difference between two groups was statistically significant ( P <0 05) Conclusions Intrahepatic biliary canaliculi ultrastructure could be used as one of the prognostic factors in congenital biliary atresia