Apolipoprotein E gene polymorphism and its association with human longevity in the Uygur nationality in Xinjiang |
| |
Authors: | Wang Xinli Wang GuoQong Yang ChenRong Li Xuan |
| |
Affiliation: | Department of Pediatrics, Third Teaching Hospital of Peking University, Beijing 100083, China;Departmen of Environmental Health, Xinjiang Medical University, Wulumuqi 830054, China;The First Teaching Hospital of Xinjiang Medical University, Wulumuqi 830054, China;The First Teaching Hospital of Xinjiang Medical University, Wulumuqi 830054, China |
| |
Abstract: | OBJECTIVE: To study the relationship between apoE alleles and life-span. METHODS: Apolipoprotein E genotypes were determined in 164 unrelated Uygurs including 35 persons aged 90 years or older, 71 men aged 20-35 and 54 men with myocardial infarction by using polymerase chain reaction-restriction fragment length polymorphism. Apolipoprotein E gene polymorphism was analyzed among three groups. RESULTS: There was statistically significant difference in the epsilon 4 allele frequencies among three groups. The epsilon 4 allele frequency in olds was the lowest (0.057), while in patients suffering from myocardial infarction (MI) was the highest (0.213). In MI patients the average age of first attack in epsilon 4 allele carriers was significantly younger than that of non-carries, 51.3 and 58.3 years, respectively (P < 0.05). CONCLUSION: ApoE genotype may have some impact on human longevity. |
| |
Keywords: | apolipoprotein E gene longevity Uygur |
本文献已被 CNKI 万方数据 等数据库收录! |
| 点击此处可从《中华医学杂志(英文版)》浏览原始摘要信息 |
|
点击此处可从《中华医学杂志(英文版)》下载全文 |
|