基因芯片技术及其在疾病研究中的应用

人类基因组计划（human genome project,HGP）的完成,极大地带动了人类疾病相关基因的定位、克隆、结构与功能研究。人类基因组草图基本绘就之后,人类基因组计划也由此加入到功能基因组时代;生命科学的重点也由基因序列研究上升为基因功能研究,基因芯片就是在这个背景下发展起来的一项先进技术。与传统方法相比,它具有快速、高通量、高准确性、低成本等特点,能够满足临床基因检测的要求;且其操作简单、易于标准化、适于推广,显示出广阔的临床应用前景。本文就基因芯片技术的研究进展及其在疾病研究中的应用做一简要综述。

Gene chip technology and its application in diseases research

The Human Genome Project（Human Genome Project,HGP） has successfully completed,which greatly stimulate the study of structure and function,positioning,cloning of the human disease-related genes.After the basic human genome draft had been drawn,the HGP also enter into the functional genomics era;the focus of life science resesrch has also escalated from the study of gene sequences into gene function studies.Therefore the advanced technology of Gene chip has developed gradually.Being different from those traditional methods,such as low time and money consuming,high performance and accuracy,which make gene chip fit to be used in clinic gene testing.In addition,its features of easy manipulation,standardization and popularization endue it perfect prospect in clinical application.The goal of this review is to outline the progress of gene chip teachnology and it＇s application in the study of disease.