苦参素联合聚肌胞治疗慢性乙型肝炎肝硬化的疗效观察

目的探讨苦参素与聚肌胞联合治疗慢性乙型肝炎、肝硬化的疗效。方法随机抽取129例HBV—DNA（＋）、肝功能异常的慢性乙肝病患者，采用苦参素注射液联合聚肌胞肌注，配合保肝治疗；定期观察肝功能、HBV—DNA、肝胆B超，一般治疗1～2疗程（3—6个月），停药后观察1年以上。结果治疗1疗程肝功能恢复正常者89．1％；HBV—DNA未转阴者继续治疗，治疗结束时HBV—DNA转阴率61．2％，停药1年内血清HBV—DNA复阳率35．4％，肝功能异常复发率40．8％；复阳后重新治疗仍然有效，血清HBV—DNA再次转阴率68．7％。结论以苦参素联合聚肌胞为主，配合保肝降酶治疗，抗HBV的近期疗效确切，伴随疗程的延长，HBV—DNA转阴率增加，但是停药后有复发现象，重新用药依然有效。

Observation on therapeutic efficacy of kushenin and polyinosinicacid - polycytidylic acid in the treatment of chronic hepatitis B and hepatic cirrhosis

Objective To investigate the therapeutic efficacy of kushenin and polyinosinieacid -polycytidylic acid in the treatment of chronic hepatitis B and hepatie cirrhosis. Methods One hundred and twenty - nine chronic hepatitis B patients or hepatis cirrhosis patients with positive HBV - DNA, and abnormal liver function were randomly selected, and were treated by intra - muscular injection of kushenin and polyinosinicacid - polycytidylic acid, combined with liver - protecting treatment. The regular observation of liver function, HBV - DNA, hepatobiliary B - ultrasound examination were performed. The patients were observed for over one year after drug withdrawal. Results The clinical efficiency rates whose liver function was recovered to the normal level after I course of treatment was 89.1%. the HBV - DNA negative conversion rate at the end of treatment was 61.2%. For the patients with positive conversion of HBV - DNA during one year withdrawal poriod, the retreatment was still effective. Conclusion Kushenin and polyinosinicacid - polycytidylic acid combined with liver - protecting and enzyme reducing treatment has obvious short - term efficacy on anti - HBV. With treatment prolonged, HBV - DNA negative conversion rate will in- crease and recurrence was observed in withdrawal period, however the retreatment will be still effective.