肾母细胞瘤的血管生成调节因子和多药耐药研究进展

肾母细胞瘤（Wilms tumor，WT）是小儿常见的恶性实体肿瘤，随着放疗、化疗和手术治疗水平的进步极大提高了WT的生存率，尽管如此，仍有部分患儿预后不佳，肿瘤复发、转移和化疗失败是主要原因。肿瘤的复发和转移，对化疗药物的不敏感与肿瘤的血管生成调节和多药耐药有关，该文总结了目前WT所研究的血管生成调节因子和多药耐药因子及其作用机制，为提高该症的治疗效果提供基础研究参考。

Reaserch of vascularization regulatory factor and multidrug resistence in Wilms tumor

Wilms tumor （WT） is the most common malignent renal solid tumor in children. Dramatic im- provements in survival have occurred as the result of advances in surgical management, irradiation and chemotherapy, however some eases are in poor prognisis and recidivation, metastasis and the fail of chemotherapy are the main cause. The tumor＇ s recidivation, metastasis and insensitivty to chemotherapy are correlated with vascularizative regu- latoy and multidrug resistence. With the purpose of improving the therapeutic effect and survival , this article summa- rize current researches in WT and their mechanism of action.