墓头回提取液对小鼠移植瘤U14瘤体内微血管密度VEGF和bFGF表达的影响

目的探讨墓头回提取液对小鼠宫颈癌U14移植瘤瘤体组织微血管密度、VEGF、bFGF表达的影响。方法将SPF级雌性KM小鼠随机分成墓头回提取液高、中、低剂量组、顺铂组及模型组，以观察墓头回提取液对U14实体瘤肿瘤组织微血管密度、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）表达的影响。结果墓头回提取液高、中剂量组和顺铂组的宫颈癌U14移植瘤瘤体内微血管密度均明显低于模型组；墓头回提取液高、中剂量组和顺铂组均可降低U14移植瘤瘤体内VEGF的表达；墓头回提取液高剂量组和顺铂组均可降低U14移植瘤瘤体内bFGF的表达。结论墓头回提取液能明显抑制U14移植瘤瘤体血管形成，并能降低VEGF、bFGF的表达，提示墓头回提取液有抗肿瘤作用。

Effect of the extracting solution from mutouhui on the microvessei-density and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma

Objective To explore the effect of the extracting solution from mutouhui on the microvesseldensity and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma. Methods The SPF female mice were divided into high dose/middle dose/light dose of the extracting solution group, cisplatin group and model group randomly. Then the effect of the extracting solution from mutouhui on the microvessel-density and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma were observed. Results The microvessel-density in high dose/middle dose of extracting solution group and eisplatin group was lower than that in model group; VEGF expression in high dose/middle dose of extracting solution group and eisplatin group was lower than that in model group; bFGF expression in high dose/ middle dose of extracting solution group and cisplatin group was lower than that in model group. Conclusion The extracting solution from mutouhui is against the formation of the microvessel-density in U14 transplanted tumor, and it also can reduce the VEGF/bFGF expression, all these show that extracting solution from mutouhui has the effect of anti-tumor.