甲钴胺治疗化疗后周围神经病变的疗效观察

目的探讨甲钴胺治疗化疗后周围神经毒性的疗效。方法将2006—11～2008—1176例化疗后出现周围神经病变的患者随机分成两组。其中治疗组38例,予以甲钴胺500μg,肌肉注射治疗,1S／d;对照组38例,予维生素B12500μg,肌肉注射治疗,1次/d。疗程均为半个月。结果治疗组有效率92．1％,对照组有效率34．2％,两组疗效比较差异有统计学意义（P〈0．01）。结论甲钴胺可以明显改善化疗后的周围神经病变。

Clinical investigation on efficacy of mecobalamine in treating patients with chemotherapy-induced peripheral neuropathy

Objective To investigate the efficacy of mecobalamine in treating patients with chemotherapy-induced peripheral neuropathy. Methods Between November 2006 and November 2008, 76 cancer patients with chemotherapy-induced peripheral neuropathy were randomly assigned into the study group and the control groop. Thirtyeight patients in the study groop received intramuscular injection of mecobalamine in a dose of 500 μg, once daily, whereas thirty-eight patients in the control groop received intramuscular injection of vitamin B12 in a dose of 500 μg, once daily, the treatment duration for both groop was fifteen days. Results A significantly higher overall response rate was found in the study groop compared with those in the control groop （92. 1% versus 34. 2%, P 〈 0. 01 ）. Conclusion Mecobalamine is effective in treating chemotherapy-induced peripheral neuropathy.