清开灵注射液对脓毒症患者炎症反应的拮抗作用

Antagonistic effects of Qingkailing injection on the inflammation reaction in the patients with sepsis

Objective To explore the anti-inflammation effects of Qingkailing injection in treating sepsis. Methods Sixty patients with sepsis were randomly divided into the treatment group and the contrast group. Both groups were treated by normal western medicine and Qingkailing injection was added to the treatment group. The activation of NF-κB and the level of TNF-α were examined by ELISA method in both group before and after the treatment, and the complications were observed in both group after the treatment. Results The activation of NF-κB and the level of TNF-α in the treatment group were decreased obviously after treatment while no diference was found in the contrast group. The occurrence ratio of complication in the treatment group was significantly lower than that in the contrast group. Conclusion Qingkailing injection can resist the inflammation reaction of sepsis,interdict the pathology response process of systemic inflammatory response syndrome（SIRS）and improve the prognosis of sepsis.