普罗布考对高血压合并糖尿病患者尿微量白蛋白影响

目的探讨抗氧化剂普罗布考对高血压病合并糖尿病患者尿微量白蛋白的影响。方法选正常对照组60例，高血压病合并糖尿病患者88例，高血压病患者110例，糖尿病（非胰岛素治疗）患者92例，分别测血尿陉微球蛋白（β2-MG）和尿微量白蛋白（Alb），在降压降糖基础上并用抗氧化剂普罗布考治疗高血压病合并糖尿病患者12周，测血尿β2-MG和尿微量Alb。结果与正常对照组相比，其他各组血尿β2-MG、尿Alb均较高，抗氧化剂普罗布考治疗高血压病合并糖尿病患者后，血尿β2-MG、尿Alb、较治疗前减低（P〈0．05）。结论高血压、糖尿病均使血尿＆MG和尿微量Alb升高，高血压病合并糖尿病更甚，抗氧化剂普罗布考有助于降低尿微量白蛋白，保护肾功能。

Effect of the administration of antioxidant Probucol on micro albumin in urine in patients with both hypertension and diabetes

Objective To study the influence of antioxidant Probucol on urine β2 microglobulin （β2 - MG） and micro albumin （Alb） in patients with hypertension and diabetes. Methods Levels of blood and urine β2 - MG and urine micro/Lib were measured on normal control （ n = 60） and patients with hypertension （ n = 110）, diabetes （non insulin treatment） （ n = 92）, and both hypertension and diabetes （n = 88） before treatment. The combination of antihypertensive and hypoglycemic and the administration of antioxidant Probucol were stopped after 12 weeks, and the protein levels were measured for comparison. Results Levels of blood and urine β2 - MG and urine micro Alb were generally higher in patients than those in control. With the treatment of combination of antihypertensive and hypoglycemic plus Probucol, the protein levels were decreased significantly in patients with both hypertension and diabetes （ P 〈 0.05）. Conclusion Either hypertension or diabetes can increase the protein level of blood and urine β2- MG and urine micro Alb. Furthermore, they have additive effect on patients. Antioxidant Probucol is able to lower the level of micro Alb in urine, therefore protect function of kidney.