老年代谢综合征患者纤维蛋白原与冠状动脉病变的关系

目的探讨老年代谢综合征患者血浆纤维蛋白原水平与冠状动脉病变程度的关系。方法回顾性分析行冠脉造影的老年代谢综合征患者157例，所有患者均测体重指数、非同日血压、血脂脂蛋白谱、空腹血糖和糖负荷后2h血糖；代谢综合征的诊断标准按照中华医学会糖尿病学会的标准；冠状动脉狭窄直径≥50％为有意义病变，冠状动脉病变程度采用Gensini积分。结果老年代谢综合征患者冠心病组的血浆纤维蛋白原较对照组高（P〈0．01），纤维蛋白原升高使冠心病患病的相对危险度增加。结论冠心病作为代谢综合征的主要临床后果之一，除积极控制基本危险因素外，还应关注和干预治疗危险标志物纤维蛋白原。

The relation between the plasma fibrinogen and the pathological degree of coronary artery in the aged patients with metabolic syndrome

Objective To explore the relation between the plasma fibrinogen and the pathological degree of coronary artery in the aged patients with metabolic syndrome. Methods Retrospective analysis of angiographic coronary artery disease of 157 patients with metabolic syndrome was carried out. Each patient＇s body mass index （BMI）, non-same date blood pressure, blood fat lipoprotein, fasting blood glucose （FBG）, and two hours postprandial blood glucose（PBG2h） were measured. According to the standard of Chinese Medical Association Diabetes Society, metabolic syndrome was diagnosed. Essential pathological degree of coronary artery was associated with the narrow diameter of coronary. The coronary diameter stenosis ≥50 % was regarded as the significant lesions. The pathological degree of coronary artery adopted Gensini integral. Results Along with the age growth, the pathological changing degree of coronary artery aggravated. The levels of plasma fibrinogen in the aged patients were higher than that in the control group（P〈0.01 ） . The fibrinogen elevating caused increasing of relative risk （RR） of coronary disease. Conclusion Coronary disease is one of main clinical consequences of metabolic syndrome. Besides positively controlling the basic dangerous factors, we should also pay attention to and give intervention treatment to the dangerous factor plasma fibrinogen.