单唾液酸四己糖神经节苷脂对弥漫性轴索损伤的疗效观察

目的探讨单唾液酸四己糖神经节苷脂（GM1）在弥漫性轴索损伤（DAI）中的应用效果及其机制。方法80例弥漫性轴索损伤患者随机分为GM1治疗组（n=40）和胞二磷胆碱治疗对照组（n=40）,疗程20日,观察治疗期间患者的意识变化和远期疗效。结果（1）与对照组比较,治疗2周后,治疗组患者的意识明显改善,两组比较差异有统计学意义（P〈0.01）;（2）治疗组治愈率60.0%,总有效率90.0%,对照组为37.5%和72.5%,两组比较差异有统计学意义（P〈0.05）。结论单唾液酸四己糖神经节苷脂治疗弥漫性轴索损伤患者具有较好的催醒作用,缩短昏迷时间,降低伤残率。

Observation on curative effect of monosialotetrahexosyl ganglioside in the treatment of diffuse axonal injury

Objective To investigate the curative effects and the acting mechanism of monosialotetrahexosyl ganglioside（GM1） in the treatment of diffuse axonal injury.Methods Eighty patients with diffuse axonal injury were randomly divided into two groups,40 patients in the treated group were treated with GM1 injection and 40 patients in control group with citicoline injection.The treatment course were 20 days.The changes of the patients＇consciousness during the treatment and the late result were observed.Results Compared with the control group,consciousness of the patients in the treated group improved obviously after two weeks of treatment with statistically significant difference（P〈0.01）.The recovery rate and the total effective rate in the treated group was 60.0% and 90.0%,and that in the control group was 37.5% and 72.5%,the comparison between the two groups showed statistically significant difference（P〈0.05）.Conclusion Monosialotetrahexosyl ganglioside possesses better awake action in the treatment of patients with diffuse axonal injury.It can reduce the duration of coma and the incidence of disability.