盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒的疗效对比分析

目的观察盐酸戊乙奎醚与阿托品治疗急性有机磷农药中毒的疗效。方法选择47例急性有机磷农药中毒患者随机分为治疗组和对照组，治疗组予盐酸戊乙奎醚＋氯磷定治疗；对照组予阿托品＋氯磷定治疗。结果治疗组与对照组相比，症状消失时间、住院时间、住院费用、不良反应发生率均显著降低（P〈0．01），治愈率提高（P〈0．01），给药次数、用药量显著地减少（P〈0．001）。结论盐酸戊乙奎醚治疗有机磷农药中毒明显优于阿托品，值得临床推广应用。

Analysis of curative effect between changtuoning and atropine on cases with organophosphorus poisoning

Objective To observe the effect of the penehyclidine hydrochloride and atropine on the treatment of acute organophosphorus pesticides poisoning. Methods Forty and seven cases with oral organophosphorus pesticide poisoning were randomly divided into the control group and the therapeutic group. Patients in the control group were treated with atropine and pralidoxime chloride, and patients in the therapeutic group were treated with penehyclidine hydrochloride and pralidoxime chloride. Results The course of disease, hospitalization expense, incidence of overdose, incidence of side reactions in the therapeutic group differed markedly from the control group（ P 〈 0.01）. The times of administrating drugs in the penehyclidine hydrochloride group were less than that in the atropine group（ P 〈 0.001）. Conclusion The efficacy of penehyclidine hydrochloride in treating organophosphorus pesticide poisoning was significantly better than that of atropine. So penehyclidine hydrochloride is worth generalizing and applying clinically.