病毒性心肌炎患儿血管细胞黏附分子-1白细胞介素-6的改变及临床意义

目的了解可溶性血管细胞黏附分子-1（sVCAM—1）、白细胞介素石（IL-6）在病毒性心肌炎中的改变及意义。方法取外周静脉血，采用双抗体夹心ELISA法检测sVCAM-1、IL-6。结果病毒性心肌炎sV-CAM-1（1376．8±54．76ng／m1）较对照组（714．85±276．54．g．／m1）明显增高（P〈0．01）。病毒性心肌炎IL-6（99．524-54．58pg／m1）较对照组（54．614-32．41pg／m1）明显增高，两者差异有统计学意义（P〈0．01）。病毒性心肌炎患儿血清sVCAM-1、IL-6呈正相关，r=0．3210。结论sVCAM—1、IL-6在病毒性心肌炎患儿中明显增高，并在病毒性心肌炎发病过程发挥作用。

The changes and clinical significance of the human vascuolar cell adhesion molecule 1 and interleukin-6 in the children with viral myocarditis

Objective To study the changes of the human soluble vascuolar cell adhesion molecule 1 （ sV- CAM-1 ）and interleukin-6 （IL-6） and their clinical significance in the children with viral myocarditis. Methods Thirty-seven children who suffered viral myocarditis were chosen as the study group and twenty-eight health children received physical examination as the control group. The sVCAM-1 and IL-6 were detected in the blood samples taken from the children of both groups with the double antibody sandwich enzyme linked immunosorbent assay, and then the changes between the two groups were compared and their dependability were evaluated. Results The concentration of sVCAM-1 in study group（1376. 8 -＋54. 76 ng/ml） was significantly higher than that in the control group（714. 85 ± 276. 54 ng/ml） （P 〈0. 01 ）. As for the IL-6, it is almost the same result. Furthermore the two indexes showed direct correlation,r =0. 3210. Conclusion The significantly higher concentration of sVCAM-1 and IL-6 in children with viral myocarditis play very important role in the pathogenesis of viral myocarditis.