社区获得性肺炎50例病原菌调查及耐药分析

目的了解社区获得性肺炎（CAP）的病原菌分布及耐药情况，为合理使用抗生素提供依据。方法收集2007—03～2008—06发病的50例社区获得性肺炎患者的痰液，做常规细菌培养鉴定，用NCCL2005推荐指南的K—B纸片法进行体外药敏试验。结果病原菌中革兰氏阴性菌占74％，革兰氏阴性菌对头孢唑啉、氨苄西林、环丙沙星耐药较为突出，对阿米卡星敏感；革兰氏阳性菌对青霉素、红霉素、阿莫西林的耐药较为突出，对头孢毗肟、万古霉素敏感。结论临床治疗应重视病原菌检测及耐药试验，为临床合理使用抗生素提供依据，预防细菌耐药性增加，提高治愈率，降低医药费。

Pathogens survey and drug - resistant analysis in 50 cases of community - acquired pneumonia

Objective To understand the pathogen distribution and drug resistance of community - acquired pneumonia （CAP）, in order to provide the basis for the rational use of antibiotics. Methods From March 1,2007 to June 1,2008 the sputum from 50 cases of community - acquired pneumonia were collected for conventional bacterial culture and for drug sensitive test, with guidelines recommended NCCL2005 paper KB vitro method. Results In the pathogens, resistance of gram - negative bacteria （74%） to eefazolin, ampicillin, ciprofloxacin is more prominent, sensitive to amikacin; resistance of gram -positive bacteria to penicillin, erythromycin, amoxicillin is more prominent, sensitive to cefepime, vancomyein. Conclusion The clinical treatment should pay attention to pathogen detection and resistance test, in order to provide the clinical basis for the rational use of antibiotics to prevent bacterial resistance, increase the cure rate and reduce medical expenses.