| 厄贝沙坦达稳态时对兔体内环孢素A药动学的影响 |
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| 引用本文： | 钱小蔷,张九如,周卫,汤坚,刘心慧,尚如霞,汪华君.厄贝沙坦达稳态时对兔体内环孢素A药动学的影响[J].中国医院药学杂志,2010(1). |
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| 作者姓名： | 钱小蔷 张九如 周卫 汤坚 刘心慧 尚如霞 汪华君 |
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| 作者单位： | 江苏大学附属医院;镇江市药品检验所; |
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| 基金项目： | 江苏省临床药学科研基金资助课题—“默沙东”科研基金课题(编号:L07011) |
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| 摘 要： | 目的:研究厄贝沙坦对家兔体内环孢素A(CsA)药动学的影响。方法:采用荧光偏振免疫法测定6只家兔单用CsA及合用厄贝沙坦后CsA的血药浓度,并对2组药动学参数进行统计学分析。结果:合用厄贝沙坦后CsA的峰浓度(Cmax)显著升高(P<0.01),曲线下面积(AUC0→24)显著增大(P<0.01),血浆清除率(CL)及表观分布容积(V)显著降低(P<0.05),其余药动学参数无显著性变化。结论:厄贝沙坦可升高CsA的血药浓度,建议临床上两药合用时须监测CsA的血药浓度,保证治疗安全有效。
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| 关 键 词： | 环孢素A 厄贝沙坦 药动学 |
Influnce of irbesartan on pharmacokinetics of cyclosporin A in rabbits |
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| QIAN Xiao-qiang,ZHANG Jiu-ru,ZHOU Wei,TANG Jian,LIU Xin-hui,SHANG Ru-xia,WANG Hua-jun.Influnce of irbesartan on pharmacokinetics of cyclosporin A in rabbits[J].Chinese Journal of Hospital Pharmacy,2010(1). |
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| Authors: | QIAN Xiao-qiang ZHANG Jiu-ru ZHOU Wei TANG Jian LIU Xin-hui SHANG Ru-xia WANG Hua-jun |
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| Institution: | QIAN Xiao-qiang1,ZHANG Jiu-ru1,ZHOU Wei2,TANG Jian1,LIU Xin-hui1,SHANG Ru-xia2,WANG Hua-jun1(1.The Affiliated Hospital of Jiangsu University,Jiangsu Zhenjiang 212001,China,2.Zhenjiang Institute for Drug Control,Jiangsu Zhenjiang 212003,China) |
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| Abstract: | OBJECTIVE To study the influnce of irbesartan on pharmacokinetics of cyclosporin A(CsA) in rabbits.METHODS The CsA concentrations in blood were measured by fluorescence polarization immunoassay in six rabbits using CsA alone and the combination of irbesartan,the pharmacokinetic parameters of the two groups were statistically analyzed.RESULTS The Cmax of CsA was significantly increased after combination of irbesartan(P<0.01),AUC increased significantly(P<0.05),CL and V significantly decreased(P<0.05),the rem... |
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| Keywords: | cyclosporine A irbesartan pharmacokinetics |
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