安心颗粒对冠心病患者血浆同型半胱氨酸的影响

目的:观察安心颗粒对冠心病患者同型半胱氨酸(Hcy)的干预作用。方法:将60例冠心病患者随机分为A、B2组各30例。A组给予安心颗粒(由人参、桂枝、瓜蒌、水蛭、茯苓等组成)治疗,B组给予叶酸、维生素B12治疗。4周为1疗程。结果:A组显效10例,有效14例,无效6例,总有效率80.0％;B组显效4例,有效12例,无效14例,总有效率53.3％。2组比较,差异有显著性意义(P<0.05)。心电图改善率A组为55.5％、B组为20.0％,2组比较,差异有非常显著性意义(P<0.01)。硝酸酯类药停减率A组为88.2％,B组为27.8％,2组比较,差异有非常显著性意义(P<0.01)。治疗前2组Hcy含量均较正常对照组增高(P<0.05),治疗后Hcy含量均降低(P<0.05)。但2组治疗后比较,差异无显著性意义(P>0.05)。2组临床疗效与Hcy含量变化关系中的符合率A组为80.0％,B组为53.3％。结论:安心颗粒对冠心病患者高同型半胱氨酸血症具有与叶酸、维生素B12同样的干预作用,但在改善临床症状和心电图等方面,疗效优于叶酸、维生素B12。

The Influence of Anxin Granules on Homotypic Cysteine of Plasma in Coronary Heart Disease

Objective: To observe the interferential action of Anxin Granules (AG) on homotypic cysteine (Hcy) of plasma in coronary heart disease (CHD). Methods: 60 cases of CHD were allocated to group A and B randomly (each group 30 cases). The group A was treated by AG (composed of Radix Ginseng, Ramulus Cinnamomi, Fructus Trichosanthis, Hirudo and Poria etc. ) . The group B by folic acid and vit B12. 4 weeks constituted a course of treatment. Results: In group A, 10 cases were markedly effective, 14 cases effective and 6 cases ineffective, the total effective rate was 80. 0% and 4, 12 and 14 cases and 53. 3% in group B respectively ( P < 0. 05). The improved rate of ECG was 55. 5% and 20. 0% in group A and B respectively ( P < 0. 01). The withdrawal medicine rate of esters nitrate was 88. 2% and 27. 8% in group A and B respectively ( P < 0. 01). The content of Hcy of both groups were increased than normal control group before treatment (P < 0. 05), but decreased after treatment (P < 0. 05), the comparison of both groups after treatment showed no significant difference (P > 0. 05). The coincidence rate on the relation of clinical effect and the changes of Hcy content was 80. 0% in group A and 53. 3% in group B. Conclusion: AG possesses the same interferential action as folic acid and vit B12 for Hcy of plasma in CHD, but is superior than folic acid and vit B12 for improving the clinical symptom and ECG.