| 甘草及枸杞子对IgE抗体应答的调节作用 |
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| 引用本文： | 殷金珠,金四立,白小微,郝正梅.甘草及枸杞子对IgE抗体应答的调节作用[J].北京大学学报(医学版),1992(2). |
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| 作者姓名： | 殷金珠 金四立 白小微 郝正梅 |
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| 作者单位： | 北京医科大学免疫学教研室
(殷金珠，白小微)，齐齐哈尔医学院免疫教研室
(金四立)，北京医科大学免疫学教研室(郝正梅) |
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| 摘 要： | 本文以小鼠为模型研究甘草及枸杞子对IgE合成的调节作用。结果显示,实验组小鼠血清IgE水平明显低于对照组。表明,甘草及枸杞子均可抑制小鼠IgE合成。过继转移试验及T细胞亚类分析提示,甘草抑制IgE合成是T细胞介导的,且与CD8~+细胞有关。
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| 关 键 词： | 甘草 枸杞子 IgE 免疫调节 |
REGULATORY ACTION OF GLYCYRRHIZA URALENSIS FISCH AND LYCIUM BARBARUM ON IgE ANTIBODIES RESPONSE |
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| Yin Jinzhu,et al Depart ment of Immunology.REGULATORY ACTION OF GLYCYRRHIZA URALENSIS FISCH AND LYCIUM BARBARUM ON IgE ANTIBODIES RESPONSE[J].Journal of Peking University:Health Sciences,1992(2). |
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| Authors: | Yin Jinzhu Depart ment of Immunology |
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| Abstract: | Both Glycyrrhiza uralensis FISCH,(G) and Lycium barbarum, (L) are traditional Chincse herbs.Rrgulation of IgE with G or L was studied in mice. Levels of serum DNP IgE were measured byPCA, DNP IgG by ELISA, and DNP IgE PFC for spleen cells. The results showed that G and L sig-nificantly decreased serum DNP IgE levels and DNP IgE PFC/spleen in G group was much less thancontrol. We have investigated the possible role of suppressor T cells and cytokines in inducing thedecrease of IgE antibodies. All the experiments such as adoptive transfer experiment, T subsets analy-sis and detecting suppressor factor from spleen cells culture supernatant have suggested that immuno-suppression of IgE response with G could be achieved by enhancing the production of suppressor Tcells and regulating the function of T cells and cytokine secretion. |
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| Keywords: | Glycyrrhiza uralensis FISCH Lycium barbarum IgE Immunoregulation |
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